Study of Postoperative Cognitive Decline in Aged Patients

Jia-feng Wang

Status: Unknown

Conditions: Cognitive Decline

Study type: Observational

Funder types: Other

Identifiers

NCT03765840

POCD-aged

Details and patient eligibility

About

postoperative cognitive decline is a common and deleterious complication in aged patients.The link between inflammation and postoperative cognitive decline has also been reported.However,the link between SOD1，SOD2，Osteopontin， Kallikrein-6，and Contactin-1 and postoperative cognitive decline is unknown. In this project ,investigators examine the relationship between 5 cytokines measured at there timepoints (preoperative [PREOP], postoperative day 1 [POD1] , and postoperative day 3[POD2]) and postoperative cognitive decline among older adults undergoing orthopedic surgery.

Enrollment: 300 estimated patients

Sex: All

Ages: 65 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients who are more than 65 years old
• patients who undergo orthopedic surgery(trauma ,especially fracture of lower limb)
• patients with ASA physical status I-III
• patients who have a consent

Exclusion criteria

• patients who are more than 85 years old
• patients with ASA physical status >III
• patients who have neurological disorders, stroke or other affective central nervous system diseases
• patients who have a history of serious psychiatric illness
• patients with long-term use of psychoactive substances
• patients who undergo multiple trauma and the presence of head injury

Trial design

300 participants in 2 patient groups

POCD group

Description:

patients occur cognitive decline after surgery according to scores in this group.

NO POCD group

Description:

patients do not occur cognitive decline after surgery according to scores in this group.