Study of Postoperative Delirium in Elderly People After Orthopedic Surgery

Zhongnan Hospital

Status: Completed

Conditions: Postoperative Delirium

Treatments: Other: interview

Study type: Observational

Funder types: Other

Identifiers

NCT02817386

2015002

Details and patient eligibility

About

The purpose of this study is to investigate the possible relationship of microRNA and postoperative delirium.

Full description

Postoperative delirium is one of the most common postoperative complications in elderly patients.It has been shown that postoperative delirium has independent adverse effects on short and long-term mortality and morbidity, including poor functional recovery, postoperative cognitive dysfunction, deterioration in quality of life, and increased costs. However, at the present time, postoperative delirium is a clinical phenomenon, and its neuropathogenesis remains unknown. This gap in knowledge has become a barrier that limits further studies, including the development of potential interventions for postoperative delirium.

Enrollment: 52 patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. 65 years old or older
2. candidates for spinal anesthesia
3. Non language communication barriers

Exclusion criteria

1. past medical history of neurological and psychiatric diseases including AD, other forms of dementia, stroke, or psychosis;
2. severe visual or hearing impairment;
3. unwillingness to comply with the protocol or procedures.

Trial design

52 participants in 1 patient group

POD and Non-POD;

Description:

Trained clinical research assistants interviewed the patients on the first and second day post surgery. The assessment of post deliriu (POD) was performed once per day between 8:00 AM to 10:00 AM. Patient notes were not reviewed for episodes of delirium which could occur outside the time of assessment. The clinical research assistants who performed the delirium assessments in this study had good training and went through quality control procedures. We used state-of-the-art delirium detection methods, which tend to report a higher incidence of delirium. The interview included the Confusion Assessment Method (CAM) and Memorial Delirium Assessment Scale (MDAS).

Treatment:

Other: interview