Study of Postprandial Incretin Response in Women With Gestational Diabetes

University Hospital, Gentofte, Copenhagen

Status: Completed

Conditions: Gestational Diabetes Mellitus

Treatments: Other: Meal test

Study type: Observational

Funder types: Other

Identifiers

NCT01274052

KA-060015

Details and patient eligibility

About

The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, C-peptide and glucagon.

The researchers aimed to investigate whether women with gestational diabetes mellitus exhibit decreased postprandial GLP-1 responses, and if so, whether this deficiency ceases following delivery when normal glucose tolerance is reestablished.

Full description

The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, C-peptide and glucagon.

The researchers aimed to investigate whether women with gestational diabetes mellitus exhibit decreased postprandial GLP-1 responses, and if so, whether this deficiency ceases following delivery when normal glucose tolerance is reestablished.

Enrollment: 19 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Normal haemoblobin
• Willingness to participate

Exclusion criteria

• First degree relative with diabetes
• Diabetes before pregnancy
• Positive islet cell- and GAD-65 autoantibodies

Trial design

19 participants in 2 patient groups

Gestational Diabetes Mellitus

Description:

Women with Gestational Diabetes Mellitus

Treatment:

Other: Meal test

Normal Glucose Tolerance

Description:

Women with Normal Glucose Tolerance

Treatment:

Other: Meal test