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Study of Postprandial Incretin Response in Women With Gestational Diabetes

U

University Hospital, Gentofte, Copenhagen

Status

Completed

Conditions

Gestational Diabetes Mellitus

Treatments

Other: Meal test

Study type

Observational

Funder types

Other

Identifiers

NCT01274052
KA-060015

Details and patient eligibility

About

The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, C-peptide and glucagon.

The researchers aimed to investigate whether women with gestational diabetes mellitus exhibit decreased postprandial GLP-1 responses, and if so, whether this deficiency ceases following delivery when normal glucose tolerance is reestablished.

Full description

The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, C-peptide and glucagon.

The researchers aimed to investigate whether women with gestational diabetes mellitus exhibit decreased postprandial GLP-1 responses, and if so, whether this deficiency ceases following delivery when normal glucose tolerance is reestablished.

Enrollment

19 patients

Sex

Female

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Normal haemoblobin
  • Willingness to participate

Exclusion criteria

  • First degree relative with diabetes
  • Diabetes before pregnancy
  • Positive islet cell- and GAD-65 autoantibodies

Trial design

19 participants in 2 patient groups

Gestational Diabetes Mellitus
Description:
Women with Gestational Diabetes Mellitus
Treatment:
Other: Meal test
Normal Glucose Tolerance
Description:
Women with Normal Glucose Tolerance
Treatment:
Other: Meal test

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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