Study of Preoperative Management of Angiotensin Converting Enzyme Inhibitor (ACEi) and Angiotensin Receptor Blocker (ARB) Medications (PASS)

Lawson Health Research Institute

Status

Completed

Conditions

Hypertension

Treatments

Procedure: Preoperative ACEi/ARB management

Study type

Interventional

Funder types

Other

Identifiers

NCT01091961

R-09-487

16503 (Other Identifier)

Details and patient eligibility

About

Patients on a stable dose of ACE inhibitor or ARB medication who are scheduled for elective surgery will be randomized to take their ACE inhibitor or ARB up to and including the morning of surgery, or to hold them a day prior to the surgery. The patients will be followed for 30 days after surgery to assess any adverse health outcomes.

Enrollment

200 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

currently taking an ACEi, ARB or both
no change in these medications during the two weeks prior to study enrollment
scheduled for non-cardiac surgery requiring regional or general anesthesia
minimum overnight anticipated length of stay
age ≥18 years.

Exclusion criteria

explicit instructions provided to patient by surgical team regarding the perioperative management of ACEi or ARB
significant hypertension in pre-operative assessment clinic (systolic blood pressure ≥180 mmHg OR diastolic blood pressure ≥110 mmHg)
significant hypotension in pre-operative assessment clinic (systolic blood pressure < 90 mmHg)
prior enrollment in the study
participation in another research study of antihypertensive medications