Study of Prevalence of Colorectal Adenoma in 30- to 49-year-old Subjects With a Family History of Colorectal Cancer

Asan Medical Center

Status: Unknown

Conditions: Colorectal Neoplasms

Study type: Observational

Funder types: Other

Identifiers

NCT01428752

ADENOMA 30-49 YO

Details and patient eligibility

About

Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer are controversial. The aim of this study was to prospectively define the prevalence of colorectal adenoma 30- to 49-years-old asymptomatic subjects with a first relative history of colorectal cancer and to compare the data with controls.

Design: Single-center prospective study

Full description

Colorectal cancer screening is recommended for average-risk persons beginning at age 50. A family history of colorectal cancer is recognized as a risk factor for colorectal adenoma. However, the strength of this association is uncertain. Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer have proved controversial. The conflicting recommendations are partly attributable to the lack of data about the prevalence of CRC and adenomas among 30- to 49-year-old individuals with a first relative history of colorectal cancer. This prospective study will quantify the prevalence of adenomas (any size) and advanced adenomas among 30- to 49-year-old individuals undergoing their first screening colonoscopy because of a first relative history of colorectal cancer and compare the data with controls(asymptomatic subjects without a first relative history of colorectal cancer).

Enrollment: 1,000 estimated patients

Sex: All

Ages: 30 to 49 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 30- to 49-year-old asymptomatic subjects
• First relative history of colorectal cancer

Exclusion criteria

• previous colonoscopy for any reason
• personal history of colorectal adenomas or CRC
• history of familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer, or inflammatory bowel disease
• documented history of occult GI bleeding, lower gastrointestinal tract bleeding not attributable to hemorrhoid, or
• iron deficiency anemia
• unexplained weight loss of >10% of the body weight in the 6 months before colonoscopy
• incomplete examination of entire colon

Trial design

1,000 participants in 1 patient group

Family history

Description:

30- to 49-year-old asymptomatic subjects with a first relative history of colorectal cancer