Study of Protein Metabolism in Healthy Older Subjects

Abbott

Status

Completed

Conditions

Malnutrition

Treatments

Other: Experimental protein powder sachet

Other: Control protein powder sachet

Study type

Interventional

Funder types

Industry

Identifiers

NCT02052232

BL19

Details and patient eligibility

About

This is a randomized, double-blinded, crossover study to evaluate muscle protein metabolism during fasting and feeding in healthy older subjects.

Enrollment

39 patients

Sex

All

Ages

60 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age ≥ 60 and ≤ 75 years
Body Mass Index (BMI) > 23.0 to < 30.0
Ability (with or without the aid of an assistive device) to climb a flight of 10 stairs or walk an equivalent of 1 city block without assistance
Currently not participating in a formal exercise or training program and agrees to refrain from intense physical activity from screening through the completion of the study.

Exclusion criteria

Diagnosis of diabetes
Active pursuit of weight loss
Poorly controlled hypertension or hypotension
Untreated hypothyroidism or hyperthyroidism
Anemia or abnormally functioning kidneys or liver
A significant cardiovascular event within ≤ 6 months; or stated history of congestive heart failure; or evidence of clinically active cardiovascular disease assessed during the screening EKG
Peripheral arterial disease or other diseases that preclude proper limb blood flow
Chronic, contagious, infectious disease
Current infection or corticosteroid treatment within the last 3 months
Clotting or bleeding disorders, stated history of Deep Vein Thrombosis (DVT) and/or a known hypercoagulable condition
In condition deemed unsuitable for study based upon study physician assessment
Surgery requiring >2 days of hospitalization in the last 3 weeks and/or planned elective surgery requiring >2 days of hospitalization during the course of the study
Current active malignant disease or was treated within the last 6 months for cancer
An amputee
Obstruction of the gastrointestinal tract, inflammatory bowel disease, short bowel syndrome or other forms of gastrointestinal disease
Diagnosed with, or has a history of severe dementia or delirium, eating disorder, history of significant neurological or psychiatric disorder, alcoholism, substance abuse
Cannot refrain from taking
- High doses of fish oil, or omega-3 supplements, or high doses of vitamin D
- Medications/dietary supplements/herbals or substances that are considered anabolic, or reduce weight
- Any pulmonary anti-inflammatory medication or bronchodilators on the day of and 48 hours prior to study visits 1 and 2
- NSAIDS or acetaminophen on the day of and 48 hours prior to study visits 1 and 2
Chronic use of nicotine
Allergic or intolerant to any ingredient found in the study products