Study of Proteins in Tumor Samples From Patients With Non-Small Cell Lung Cancer

Alliance for Clinical Trials in Oncology

Status: Withdrawn

Conditions: Lung Cancer

Treatments: Other: laboratory biomarker analysis

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT01415739

CALGB-151102

CDR0000706383 (Registry Identifier)

NCI-2011-02977 (Registry Identifier)

Details and patient eligibility

About

This research studies protein in tumor samples from patients with non-small cell lung cancer. Finding specific proteins in tumor tissue samples from patients with cancer may help doctors tell what type of lung cancer a patient has and plan better treatment.

Full description

PRIMARY OBJECTIVES:

I. To validate a novel 4-protein signature's ability to subtype non-small cell lung cancer (NSCLC) in a treatment-naive, multi-institutional cohort, Cancer and Leukemia Group B (CALGB) 9761.

SECONDARY OBJECTIVES:

I. To estimate the NSCLC misclassification rate in a multi-institutional clinical-trial setting for stage 1 NSCLC (adenocarcinoma versus squamous cell).

OUTLINE:

Previously collected tissue samples are analyzed via hematoxylin and eosin (H&E) staining and immunohistochemistry (IHC).

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patients must have been registered on CALGB-9761

  • Stage I disease
  • Treatment-naive patients

• A representative paraffin block of the primary tumor must be available from patients on CALGB-9761 and submitted to the CALGB Pathology Coordinating Office

• A separate consent form is not required for this study, as permission for research to be performed on the tissue blocks is included in the consent form for CALGB 9761

• Institutional review board (IRB) review and approval at the institution where the laboratory work will be performed is required

Trial design

0 participants in 1 patient group

Novel Molecular NSCLC Classification (H & E staining, IHC)

Description:

Previously collected tissue samples are analyzed via H\&E staining and IHC.

Treatment:

Other: laboratory biomarker analysis