Study of PTPN22 C1858T Polymorphism in Children and Adolescents of Greek Origin With T1DM

Aristotle University Of Thessaloniki

Status

Completed

Conditions

Type 1 Diabetes Mellitus

Study type

Observational

Funder types

Other

Identifiers

NCT01276743

01051979

Details and patient eligibility

About

The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene encodes a lymphoid-specific phosphatase (LYP) which is an important downregulatory factor of T cell activation. A PTPN22 polymorphism, C1858T, was found associated with T1DM in different Caucasian populations.

In this observational case-control study, we aimed at confirming the role of PTPN22, C1858T polymorphism in T1DM predisposition in a Greek population.

Enrollment

200 patients

Sex

All

Ages

3 to 18 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

For the patients

Diagnosis of T1DM according to American Diabetes Association (ADA) Criteria as well as according to International Society for Pediatric and Adolescent Diabetes (ISPAD) Guidelines
Unrelated male and female subjects
1-20 years of age
Come from Greece (At least 3 grandparents are Greek)
At least one year post onset of T1DM
Sign written informed consent

Inclusion Criteria:

For the controls

Unrelated nondiabetic male and female subjects with no family history of T1DM
Equal to or greater than 18 years of age
Come from Greece (At least 3 grandparents are Greek)
Be screened by a questionnaire to ensure the absence of any diagnostic evidence of autoimmune diseases or family history (first- or second-degree relatives) of T1DM
Sign written informed consent

Exclusion criteria

For the patients •Subjects who do not meet the criteria above

Exclusion Criteria:

For the controls

•Subjects who do not meet the criteria above