ClinicalTrials.Veeva

Menu

Study of Retinal Vascular Parameters in Patients With Wilson's Disease (WILLY)

F

Fondation Ophtalmologique Adolphe de Rothschild

Status

Completed

Conditions

Wilson Disease

Treatments

Procedure: Ophthalmological exam

Study type

Interventional

Funder types

NETWORK

Identifiers

NCT04408300
APS_2020_5

Details and patient eligibility

About

The rare disease reference center " Wilson disease and other rare copper-related diseases" of the Rothschild Foundation follows a large number of patients with Wilson's with varying degrees of impairment and located at different times of their care.

Many people with Wilson's disease have a characteristic greenish-brown ring, known as Kayser-Fleischer, appearing at the periphery of the cornea due to a deposit of copper at the Descemet membrane. As a general rule, if the patient is compliant with his treatment, the ring usually disappears within a few years, although it may persist in some patients. However, apart from the stage of diagnosis, and the evolution of the ring, ophthalmological examinations are little used for the follow-up of these patients.

The objective of this study is to describe the retinal parameters, in particular vascular with two new retinal imaging technologies (OCT-A :Optical Coherence Tomography-Angiography , Adaptive optics) in patients with Wilson's disease and to correlate them with the parameters of the usual follow-up of these patients (hepatic assessment, exchangeable plasma copper, neurological scores, compliance, etc.).

Enrollment

124 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Wilson's disease with Ferenci score ≥4

Exclusion criteria

  • Neurological or behavioral handicap that does not allow for ophthalmological examinations
  • Hepatic decompensation that does not allow for ophthalmological examinations
  • Pregnant or breastfeeding woman

Trial design

Primary purpose

Other

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

124 participants in 1 patient group

Ophthalmological exam
Experimental group
Treatment:
Procedure: Ophthalmological exam

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems