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The purpose of this study is to evaluate the efficacy of hypofractionated stereotactic radiation treatments (SBRT) on children, teenagers and young adults malignant tumors.
Full description
SBRT (Stereotactic Body Radiation Therapy) is a radiotherapy treatment which involves the delivery of a single high dose radiation treatment or a few fractionated radiation treatments (usually up to 5). A high potent biological dose of radiation is delivered to the tumor improving the cure rates for the tumor, in a manner previously not achievable by standard conventional radiation therapy.
For adult patients, the "Haute Authorité de Santé" (HAS) validates some indications for this treatment which are the followings :
For pediatrics patients, no indication is now validated by HAS. Indications validated for adults are rare in pediatrics but not exceptional, and in such cases efficient alternative treatments does not exist.
In consequence, and regarding the good results obtained in adult patients, it seems very important to validate the efficacy of this treatment on pediatrics population
Enrollment
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Volunteers
Inclusion and exclusion criteria
INCLUSION CRITERIA:
18 months ≤ age ≤ 20 years
Malignant primary tumor, histologically or cytologically proven
Systemic disease under control or with slow evolution
Written indication of SBRT according to local pediatrics meeting and national Radiotherapy (RT) web conference
Performance Status ≤ 2 according to Eastern Cooperative Oncology Group (ECOG)
Sites
Affiliation to a social security scheme
Signed Informed consent by patient or parents and patient
IN ADDITION FOR RELAPSING EPENDYMOMA:
NON-INCLUSION CRITERIA :
IN ADDITION FOR RELAPSING EPENDYMOMAS:
NON-RANDOMIZATION DOSIMETRIC CRITERIA (ONLY FOR EPENDYMOMA)
Primary purpose
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Interventional model
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61 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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