Study of Short Course Radiation Therapy for Elderly Patients With Rectal Cancer

University of Rochester

Status: Terminated

Conditions: Cancer, Rectal

Treatments: Radiation: Short course radiation therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT04139967

4297

Details and patient eligibility

About

This study will help determine if a short course of radiation therapy is effective to treat rectal cancer in older patients. A shorter course of radiation treatment may be better tolerated than a longer course or surgery for the treatment of rectal cancer in the elderly.

Enrollment: 2 patients

Sex: All

Ages: 70+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 70 years or older at time of diagnosis
• No restrictions on gender or ethnicity
• Ability and willingness to make follow up appointments
• Pathologic diagnosis of rectal cancer
• Presentation could be symptomatic or asymptomatic
• T1-T3 primary rectal adenocarcinoma as determined on TRUS, CT, or MRI pelvis
• Peri-rectal node positive allowed
• Inability to tolerate radical surgery, as judged by geriatric oncology or surgeon and tumor board OR patient refusal of surgery
• Inability to receive chemoradiation therapy, defined as concurrent chemotherapy and radiation doses of 45-50.4 Gy, as judged by radiation, medical, or geriatric oncology
• Patients with dementia eligible if Health Care Proxy (HCP) is available and supportive of follow up schedule

Exclusion criteria

• Age under 70 years of age
• Ability and desire to receive definitive surgical intervention
• Ability and desire to receive concurrent chemoradiation therapy

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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2 participants in 1 patient group

Elderly rectal cancer patients

Experimental group

Treatment:

Radiation: Short course radiation therapy