Study of Sildenafil in Patient With Heart Failure.

Mass General Brigham

Status and phase: Completed; Phase 3

Conditions: Congestive Heart Failure

Treatments: Drug: sildenafil

Study type: Interventional

Funder types: Other

Identifiers

NCT00309816

2001-p-001039

Details and patient eligibility

About

The purpose of this study is to determine if sildenafil (Viagra) improves exercise tolerance.

Full description

Patients will undergo an exercise stress test. One dose of Sildenafil will then be given, followed by a one hour rest period. A repeat exercise stress test will then be repeated.

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Age 18 - 75 Ejection fraction <35% Heart failure limited by fatigue and shortness of breath -

Exclusion criteria

Inability to exercise. Patients with shortness of breath while resting. Patient requiring intravenous medication. Patients taking the following medications: nitroglycerine pill/patch/paste, isordil and Imdur

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)