Study of STIM1 Membrane Expression (STIMEX)

Regional University Hospital Center (CHRU)

Status: Enrolling

Conditions: Autoimmune Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT04978948

STIMEX - 29BRC21.0025

Details and patient eligibility

About

The aim of this study is to determine the expression of STIM1 in the plasma membrane of lymphocytes from patients suffering from different autoimmune diseases in order to identify new pathologies of interest presenting an over-expression of STIM1PM.

This would allow to initiate, following this study, research and development programs on the use of anti-STIM1 antibodies in these identified autoimmune diseases of interest.

Enrollment: 670 estimated patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of one of the autoimmune diseases

Exclusion criteria

• Treatment with rituximab in the previous 12 months

Trial design

670 participants in 18 patient groups

Myasthénie

Description:

Blood samples will be collected

Myopathie inflammatoire (Myosite)

Description:

Blood samples will be collected

Neuropathie autoimmune

Description:

Blood samples will be collected

Néphropathies autoimmunes

Description:

Blood samples will be collected

Hépatite auto-immune

Description:

Blood samples will be collected

Pancréatite auto-immune

Description:

Blood samples will be collected

Purpura Thrombopénique Immunologique

Description:

Blood samples will be collected

Dermatose bulleuse

Description:

Blood samples will be collected

Thyroïdite autoimmune

Description:

Blood samples will be collected

Sclérose en plaque

Description:

Blood samples will be collected

Sclérose latérale amyotrophique

Description:

Blood samples will be collected

Polyarthrite Rhumatoïde

Description:

Blood samples will be collected

Spondylarthrite axiale

Description:

Blood samples will be collected

controls

Description:

Patients without autoimune desease\* Blood samples will be collected

Lichen plan buccal auto-immun (LPB)

Description:

Blood samples will be collected

lichen plan buccal allo-immun liée à une GvHD (" Graft versus Host Disease ")

Description:

Blood samples will be collected

Lupus érythémateux systémique

Description:

Blood samples will be collected

Sclérodermie

Description:

Blood samples will be collected