Study of Stroke Volume Variation and Pleth Variability Index as Predictors of Fluid Responsiveness

Chung-Ang University Hosptial, Chung-Ang University College of Medicine

Status and phase: Unknown; Phase 4

Conditions: Thyroidectomy; Fluid Responsiveness

Treatments: Other: HES 130/0.4 (VolulyteⓇ, Fresenius Kabi, Canada)

Study type: Interventional

Funder types: Other

Identifiers

NCT02122367

Chung-Ang UH

Details and patient eligibility

About

Appropriate indices to guide fluid therapy are essential for effective hemodynamic management during the perioperative period. Values derived from respiratory changes in arterial pressure waveform or plethysmographic waveform such as stroke volume variation and pleth variability index have been demonstrated to be able to predict fluid responsiveness in surgical or critically ill patients. Their ability to predict fluid responsiveness can be affected by factors that influence the arterial tone or the compliance of the respiratory system by position change. The aim of this prospective trial is to investigate the ability of stroke volume variation and pleth variability index to predict fluid responsiveness in the reverse trendelenberg position.

Enrollment: 48 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age ≥ 20
2. elective robot assisted thyroidectomy

Exclusion criteria

1. arrhythmia
2. BMI>30
3. valvular heart disease
4. pul hypertension
5. peripheral artery occlusive disease
6. lung disease
7. right heart failure

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

48 participants in 1 patient group

stroke volume variation, pleth variability index

Experimental group

Description:

stroke volume variation: recorded using the FloTrac/Vigileo system (Edwards Lifesciences) pleth variability index: recorded using the Masimo Radical-7 monitor (Masimo Corporation, Irvine, CA, USA)

Treatment:

Other: HES 130/0.4 (VolulyteⓇ, Fresenius Kabi, Canada)