Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease

Free University of Brussels (ULB)

Status: Completed

Conditions: Chronic Hepatitis C Virus; Alcoholic Liver Disease

Study type: Observational

Funder types: Other

Identifiers

NCT00610597

AL-ALD

Details and patient eligibility

About

Alcoholic liver disease is characterized by circulating T cell activation and liver T cell infiltration but their phenotype is poorly studied. The aim of the study is to test the hypothesis that the (CD4+ T cell secreting Interleukin-17) Th17 pathway is involved in alcoholic liver disease.

Full description

Consecutive patients undergoing transjugular liver biopsies for alcoholic liver disease or hepatitis C virus infection will be included in the study to measure plasma cytokines levels, peripheral blood mononuclear cells cytokine release and liver T cell infiltrates.

Enrollment: 49 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Alcohol excess intake and suspected liver disease
• Alcohol excess intake and clinical liver cirrhosis
• chronic hepatitis C virus infection and suspected liver disease
• chronic hepatitis C virus infection and clinical liver cirrhosis

Exclusion criteria

• bacterial or fungal infection
• immunosuppressive treatment
• other causes of liver disease

Trial design

49 participants in 2 patient groups

1

Description:

alcoholic liver disease

2

Description:

chronic hepatitis C virus infection