Study of TB Lesions Obtained in Therapeutical Surgery (SH-TBL)

Fundació Institut Germans Trias i Pujol

Status: Completed

Conditions: Tuberculosis; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Thoracic Surgery

Treatments: Procedure: therapeutical surgery for TB

Study type: Observational

Funder types: Other

Identifiers

NCT02715271

SH-TBL-1

Details and patient eligibility

About

The correlation of the morphologic, microbiological, genetic and histopathological characteristics of TB lesions obtained in therapeutical surgery with the clinical forms and features of the patients will provide essential information

1. on the role of the host in the mechanisms associated to the generation and evolution of active TB and
2. about future diagnostic and/or prognostic biomarkers of TB disease. All this information could be used for patients stratification and/or to design new therapeutic strategies.

Enrollment: 192 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing therapeutical surgery for their Pulmonary Tuberculosis at NCTLD in Tbilisi, Georgia indicated as per clinical routine

Exclusion criteria

• Non consenting to donate samples and/or data for the study

Trial design

192 participants in 2 patient groups

Retrospective cohort

Description:

Tuberculosis patients submitted to therapeutical surgery during the last 2-5 years.

Treatment:

Procedure: therapeutical surgery for TB

Prospective cohort

Description:

Tuberculosis patients prospectively submitted to therapeutical surgery.

Treatment:

Procedure: therapeutical surgery for TB