Study of tDCS for Mild Cognitive Impairment

Incheon St.Mary's Hospital

Status

Completed

Conditions

Mild Cognitive Impairment

Treatments

Device: sham-YBand (YDT-201N)

Device: YBand (YDT-201N)

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT02320890

OC14OISI0045

Details and patient eligibility

About

The primary objective of this study is to investigate whether the transcranial direct current stimulation (tDCS) improves the cognitive function in patients with Mild Cognitive Impairment (MCI)

Full description

Twenty-four patients were recruited and randomized to receive either real- or sham-tDCS over the left (anode) and right (cathode) dorsolateral prefrontal cortex (DLPFC). Their legally responsible caregivers were provided with mobile tDCS device, and were instructed to use it on the patients at the hospital. 30-minute session of the stimulation were applied 3 times a week for 12 weeks. The patients were evaluated at baseline and at Week 12.

Enrollment

16 patients

Sex

All

Ages

65 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Subjects who have a subjective memory impairment
Subjects who have Korean version of Mini Mental Status Examination score 22 or more
Subjects who have SVLT and RCFT delayed recall test scores lower than 1.5SD
Subjects who have had other cognitive impairments besides memory
Subjects who have Seoul-Instrumental Activities of Daily Living score (S-IADL) of 8 or lower
Subjects who are not dementia of Alzheimer's type
Subjects who are right-handed
Subjects who are able to read and write
Subject or legally responsible caregiver has provided informed consent

Exclusion criteria

Subjects who have a history of stroke and seizures
Subjects who have any illnesses that may disturb the patients completing the trials, including stroke, Parkinson's disease, type 1 diabetes, uncontrollable high blood pressure, Huntington's disease, cerebral palsy, liver failure, nephritis, encephalitis, meningitis, scleroma, seizures and a treatment ischemic attack.
Subjects who have neurologic problems on physical examination that cuase memory disturbances
Subjects who have a history of DSM-IV Axis I disorders
Subjects who have extremely sensitive skin
Subjects who have suffered from the cancer in 3 years
Subjects who have had a cerebrovascular neurosurgery in medical history
Subjects who have dyspnea in sitting position
Subjects who have problems with memory, language and problem-solving for 2 hours after the heart attack.
Subjects who have a history of drug or alcohol abuse (in the past 5 years)
Subjects who have a history of mental or emotional disorders (in the past 5 years)
Subjects who have been lapsed into unconsciousness for an hour because of other reasons than general anesthesia
Subjects who have a history of hospitalization due to head injury
Subjects who are unable to read even with glasses
Subject who are unable to understand the conversation due to the hearing defect (even with the hearing aid)