Study of the Aerosol Deposition With Vented and Unvented Jet Nebulizer in Healthy Subjets

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Status: Unknown

Conditions: Aerosol Drug Therapy

Treatments: Device: Vented and Unvented Jet Nebulizer

Study type: Interventional

Funder types: Other

Identifiers

NCT01428323

3.4529.10

Details and patient eligibility

About

Open-vent jet nebulizers are frequently used to promote drug lung deposition but their clinical efficacy and indications are not clear.

Our study aimed to compare inhaled mass, and lung deposition of amikacin by using a jet nebulizer (Sidestream) under two different configurations: vented and unvented coupled to a 110 ml corrugated piece of tubing.

Enrollment: 7 estimated patients

Sex: Male

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy Volunteers between 18 and 60 years old

Exclusion criteria

• Smokers
• Pathological spirometry
• History of treatment with aminoglygosides 1 month prior the study
• Known allergy to aminoglycosydes
• Any lung pathology or history of lung surgery