Study of the Angiogenesis by PET/CT in Patients With Lymphoma (RGDLymphome)

Centre Henri Becquerel

Status and phase

Completed

Phase 2

Conditions

Lymphoma

Treatments

Device: RGD K5 PET scan

Study type

Interventional

Funder types

Other

Identifiers

NCT02490891

CHB14.02

Details and patient eligibility

About

The aim of the study is to measure tumoral angiogenesis modifications by RGD-K5 PET/CT before and after 2 cycles of chemotherapy in patients with lymphoma and a large tumoral mass

Full description

After inclusion PET scans with FDG tracer and with a specific tracer of angiogenesis will be performed on patient with lymphoma. After two cycles of chemotherapy PET scans with the same tracers will be performed.

Overall survival and disease free survival will be monitored during 18 months.

Enrollment

21 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male or Female
Age ≥ 18 years old
OMS ≤ 1
Histological diagnosis of diffuse large B-cell lymphoma what ever the subtype
Presence of measurable tumor with at least a node mass superior to 3 centimeters
Stage I to IV
Inform consent signed

Exclusion criteria

Primary cerebral lymphoma
Absence of fixing on FDG-PET exam
Pregnant , child bearing, breast feeding or without effective contraception method woman
Hypersensitivity to RGD-K5
Hypersensitivity to FDG
Poorly controlled diabètes (glycemia ≥ 10 millimoles/liter)
Neoplastic disease (less than 2 years or in progression)