Study of the Aorta Adaptations to Exercise in Triathletes During Sports Season (CoATri)

Central Hospital, Nancy, France

Status: Completed

Conditions: Vascular Remodeling; Magnetic Resonance Imaging, Functional; Athletes; Stiffness, Aortic; Cardiac Remodeling, Ventricular

Treatments: Device: Cardiac MRI; Device: Applanation tonometry

Study type: Interventional

Funder types: Other

Identifiers

NCT03356301

2017-A01872-51

Details and patient eligibility

About

Regular sustained physical activity creates a cardiac remodelling : it is athlete's heart. In our preliminary work published in 2016, the investigators demonstrated in a small population of triathletes that there is also a vascular remodelling named athlete's artery. Moreover, the investigators know that left ventricle and aorta behave together like a couple. So they want to study by Cardiovascular Magnetic Resonance Imaging the impact of triathlon on the cardiac AND aortic remodelling.

Enrollment: 63 patients

Sex: Male

Ages: 18 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• to be enrolled in a social security plan.

• to have a BMI between 18,5 and 25 kg/m²

• to have received full information on the organization of the research and having signed its informed consent

• to have carried out a clinical screening adapted to the research

  *** Triathlete group:

• to have a minimum performance level: between 2h and 2h45 on an M triathlon during the past year (provide proof),

• to participate in 2018 in a long distance triathlon, i. e. at least distance L

• to have a defined training volume: less than 8 hours per week during the winter months and between 10 and 15 hours per week in preparation of the objective

  ***Control group:

• to have no more than 150 minutes of moderate physical activity per week (footing, brisk walking, cycling, etc.).

Exclusion criteria

• Persons referred to in Articles L. 1121-5 to L. 1121-8 and L1122-2 of the Public Health Code
• Cardiovascular history including Ii.e. known heart rhythm disorders
• Chronic disease: diabetes, high blood pressure...
• Long-term drug therapies that may modify cardiovascular remodeling such as Conversion Enzyme Inhibitor, Angiotensin II Receptor Antagonist,
• Active smoking, even if occasional
• Contraindication to MRI

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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63 participants in 2 patient groups

Triathletes

Experimental group

Description:

Every triathlete will realize three cardiac MRI exams.The second of those will be done at the fitness peak, 2-3 weeks before the main objective of the sports season. Training will be increased between the study beginning and the first MRI, and the second exam. After each cardiac MRI, an applanation tonometry examination will aslo be performed.

Treatment:

Device: Cardiac MRI

Device: Applanation tonometry

Controls

Experimental group

Description:

Every control subject will also realize three cardiac MRI exams if possible at the same time as the triathletes.They must be not engaged in physical activity more than 150 minutes a week on average. After each cardiac MRI, an applanation tonometry examination will aslo be performed.

Treatment:

Device: Cardiac MRI

Device: Applanation tonometry