Study of the Arachidonate 5-Lipoxygenase Enzyme in Affecting the Risk for Coronary Heart Disease

University of Florida

Status

Completed

Conditions

Coronary Heart Disease

Treatments

Drug: Placebo

Drug: montelukast

Study type

Interventional

Funder types

Other

Identifiers

NCT00379808

AHA0615253B (Other Grant/Funding Number)

06011312

Details and patient eligibility

About

The purpose of this study is to determine whether a particular substance involved in inflammation, called leukotrienes, is involved in causing heart disease to occur or to progress.

Full description

The focus of this study is to better understand why some adults develop heart disease and others do not. There are many known factors which play a role in causing heart disease, such as diet and lifestyle. Also, we know that inflammation, a process in the body which causes painful joints in arthritis or swelling at a site if injury, also contributes to heart disease. In particular, we will address whether leukotrienes, a component of inflammation, is involved in promoting heart disease. We will study this by giving subjects at high risk for heart disease a drug called montelukast which causes leukotrienes to have a reduced effect in the body. In addition for comparison, we will give other subjects a placebo for the same amount of time. These subjects will then be crossed-over and will receive either montelukast or placebo depending on which treatment they received first. We will compare these subjects using blood tests to see if subjects who take montelukast show signs of less inflammation caused by early heart disease as compared to subjects who do not.

Enrollment

22 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

-Current hypertension (blood pressure > 140/90 mmHg) or current use of anti-hypertensive medications AND

Exclusion criteria

Current use of lipid-lowering medications
Current use of montelukast
Poorly controlled hypertension, where systolic blood pressure is greater than 160 or diastolic blood pressure is greater than 100
Use of steroid drugs, non-steroidal anti-inflammatory drugs or other anti-inflammatory medications in the two weeks prior to enrollment. (low dose aspirin ( < 325 mg) is OK, but indication must be cardiovascular)
Current recreational drug use
Other cardiovascular disease or previous cardiovascular event. These include:
history of angina pectoris
history of heart failure
presence of a cardiac pacemaker
history of myocardial infarction
previous revascularization procedure
history cerebrovascular disease including stroke and transient ischemic attack
Pregnancy or lactation
Diabetes mellitus
Lactose intolerance
Contraindications to montelukast therapy
Alcoholism
Known hepatic disease
Existing chronic obstructive pulmonary disease, asthma, allergic rhinitis
Active chronic immune, infectious, neoplastic or inflammatory diseases requiring therapy (such as active Hepatitis B, Hepatitis C, human immunodeficiency virus (HIV))
Immunosuppressant therapy or known immunosuppression due to disease high density lipoprotein (HDL) < 40 mg/dL (although this would be a risk factor for heart disease, because of preliminary data which indicates that montelukast may lower HDL levels, we will exclude patients with abnormally low HDL from study)
Other criteria at investigator discretion that are deemed to make the subject a poor candidate for the study