Study of the Causal Link Between Rheumatoid Arthritis and Periodontitis Using Mendelian Randomization (RAPD-MR)

Zhibin Xu

Status: Not yet enrolling

Conditions: Periodontitis; Rheumatoid Arthritis

Study type: Observational

Funder types: Other

Identifiers

NCT06603207

KY20240918-01

Details and patient eligibility

About

This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization. Data will be sourced from genome-wide association studies (GWAS) to explore genetic associations and assess potential risk factors in an East Asian population.

Full description

The purpose of this study is to explore the causal association between rheumatoid arthritis (RA) and periodontitis using Mendelian randomization (MR). RA and periodontitis share similar inflammatory pathways and immune responses, but their causal relationship remains unclear. This study will utilize genome-wide association studies (GWAS) data from an East Asian population to identify single nucleotide polymorphisms (SNPs) associated with RA and assess their potential impact on the risk of developing periodontitis. Statistical methods such as inverse-variance weighting, MR-Egger regression, and weighted median analysis will be employed to analyze the data. The findings may provide insights into the shared genetic basis and causal relationships between these two conditions, offering potential targets for preventive strategies.

Enrollment: 220,000 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants included in the genome-wide association study (GWAS) database.
• Subjects with available genotypic data relevant to rheumatoid arthritis and periodontitis.

Exclusion criteria

• Individuals without complete genotypic data or those with missing critical phenotypic information.