Study of the Causes of the Breakdown of Muscle Fibers in Hospitalized Patients

National Taiwan University

Status: Unknown

Conditions: Myopathy; Rhabdomyolysis; Neuroleptic Malignant Syndrome; Acute Renal Failure

Study type: Observational

Funder types: Other

Identifiers

NCT01022450

200911033R

Details and patient eligibility

About

1. Analyze the various causes of breakdown of muscle fibers in hospitalized patients.
2. Analyze the characteristics of these patients in Taiwan (including the drugs history, risk factors and the incidence of complications).

Full description

1. Find the causes of breakdown of muscle fibers in hospitalized patients through medical record review.

   • especially drug-related

2. Find the risk factors of muscle fibers breakdown.

Enrollment: 2,500 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who admitted to The National Taiwan University Hospital during 2003/1/1~2008/12/31 with the following discharge diagnosis: myoglobinuria, rhabdomyolysis, myopathy, toxic myopathy, malignant hyperthermia, neuroleptic malignant syndrome, polymyositis, myalgia and had acute neuromuscular illness presentations and serum creatinine kinase (CK) more than 5 times the upper limit of normal (male > 900 IU/L; female > 835 IU/L).

Exclusion criteria

• Patients with recent myocardial infarction or stroke, unless clinical history, examination, or electromyography showed a concomitant myopathy.