Study of the Choroidal Thickness Variations After Ingestion of RedBull® Energy Drink (REDCHO)

Fondation Ophtalmologique Adolphe de Rothschild

Status: Completed

Conditions: Choroid

Treatments: Dietary Supplement: RedBull® energy drink

Study type: Interventional

Funder types: NETWORK

Identifiers

NCT02856256

MMT_2015_2

Details and patient eligibility

About

The choroid is a richly vascularized conjunctive tissue, providing the nutritive elements to the pigmentary epithelium and the photoreceptors of the retina. It drains 80% of the eye's blood. The choroidal thickness fluctuates according to the state of fullness of its constitutive vessels. The choroid and the neuroretina (separate by the pigmentary epithelium) are intimately linked and are subject to modifications during the ingestion of caffeine and taurine combined. Several authors have shown a significant decrease of the choroidal thickness lasting at least 4 hours after the ingestion of a small coffee. This decrease may be caused by caffeine's vasoconstrictor effect. Taurine is the most abundant amino acid in the retina. Recent studies have shown the importance of this amino acid in the physiology of both, retinal pigmentary epithelium and retinal ganglion cells.

RedBull® is an energizing drink, where one single 25 cl can contains 80 mg of caffeine (the equivalent of a coffee mug) and 1 g of taurine.

This pilot trial aims to study the variations of the choroidal thickness and to describe possible modifications within the pigmentary epithelium, due to the ingestion of caffeine and taurine. The results of this study will act as a reference for an ulterior trial aiming specific choroidal pathologies of young patients, such as the central serous chorioretinitis.

Enrollment: 20 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ages 18-45 years old
• subject under no medical treatment who can alter choroidal depth (sildenafil, diuretics, steroids, etc)
• Non smoker
• subject who has not ingested any caffeine within the 12 hours prior to the trial's inclusion
• subject well informed of the trial and having signed consent

Exclusion criteria

• subject with retinal and/or choroidal abnormalities
• Diabetic subject
• Hypermetropia > +3 diopters and myopia < -3 diopters
• History of intra-ocular surgery or laser
• subject with a history of retinal pathologies
• Subject not affiliated to French social security
• Subject under juridical protection
• Pregnant woman

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

RedBull® energy drink

Experimental group

Treatment:

Dietary Supplement: RedBull® energy drink