Study of the Corelation Between Circulating Nuclearsome and SIRS Happened After Congential Cardiac Surgery

Shanghai Jiao Tong University

Status: Completed

Conditions: Congential Cardiac Surgery

Study type: Observational

Funder types: Other

Identifiers

NCT02325765

EY05.055

Details and patient eligibility

About

In this study，the investigators want to determine the corelation between circulating nuclearsome and the development of SIRS occured after congenital cardiac surgery, including the serverity of organ damage and inflamation.

Full description

Blood was collected from study participants at 6 time points; 1) post-anesthesia induction, 2) post-op hour 0, 3) post-op hour 4, 4) post-op hour 24, 5) post-op hour 48, and 6) post-op hour 72. At each of the 6 time points blood was analyzed for levels of the following:histone,blood routine test , c-reaction protein, procalcitonin, N-terminal pro-brain natriuretic,the hepatorenal function，cardiac function and pulmonary function

Enrollment: 100 patients

Sex: All

Ages: 1 month to 3 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children with congenial heart disease

Exclusion criteria

• Less than 2.5kg
• Prematurity less than 37 weeks estimated gestational age
• Renal failure as described by the pediatric RIFLE criteria

Trial design

100 participants in 2 patient groups

category of RACHS-2 for cardiac surgery

Description:

ASD \& VSD repair; VSD repair; Tetralogy repair; Tetralogy repair

category of RACHS-3 for cardiac surgery

Description:

DORV repair with or without RV obstruction; AVSD (complete or transitional) repair with or without valve replacement; Coarctation \& VSD repair