Study of the Correlation Between Muscle Oxygenation and Motor Function in Children With Neuromuscular Disease. (OXMNM)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Neuromuscular Diseases in Children; Neuromuscular Diseases in Infants

Treatments: Other: Muscular oximetry

Study type: Observational

Funder types: Other

Identifiers

NCT03471676

RIPH3-RNI17/OXMNM

2017-A02931-52 (Other Identifier)

17.11.07 (Other Identifier)

Details and patient eligibility

About

Preliminary data underline the fact that muscular deoxygenation during training happens earlier in adult patients suffering from neuromuscular disorders in comparison to controls. Up to date, pediatric data are lacking.

The study aims at demonstrating if a correlation exists between the motor deficiency and the muscular deoxygenation in children suffering from neuromuscular disorders.

Full description

Preliminary data underline the fact that muscular deoxygenation during training happens earlier in adult patients suffering from neuromuscular disorders in comparison to controls, as it was demonstrated in Becker muscular dystrophy patients and fascioscapulo humeral muscular dystrophy. Moreover, the deoxygenation kinetics was positively correlated to the functional status and the muscular deficiency severity. However, no pediatric study has been conducted on this topic up to date.

The aim of the study is to determine if a correlation exists in children suffering from neuromuscular diseases:

• between muscular oxygenation and the percentage of the 6 minutes walking test performed in the routine medical care
• between muscular oxygenation and the total and D1 motor function measure value

Enrollment: 40 patients

Sex: All

Ages: 6 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children from 6 to 18 years-old suffering from a neuromuscular disorder
• Able to walk, with or without help

Exclusion criteria

• Hypoxia secondary to heart or lung disease
• Visual impairment (<5/10)
• Parents refusal concerning data storage

Trial design

40 participants in 1 patient group

Muscular oximetry

Description:

6 minutes walking test performed in the routine medical care with muscle oximetry recording in children suffering from neuromuscular diseases

Treatment:

Other: Muscular oximetry