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Study of the Correlation Between Specific Genes and Cognitive Dysfunction After Surgery

H

Herlev Hospital

Status

Completed

Conditions

Genotype
Cognitive Impairment

Treatments

Genetic: Genotyping

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

The purpose of this study is to determine whether a certain clock-gene (HPER3) with the 5/5 genotype carries a higher risk of post-operative cognitive dysfunction.

Enrollment

279 patients

Sex

All

Ages

40+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patients undergoing non-cardiac and non-neurological surgery in either regional or general anesthesia

Exclusion criteria

  • daily use of major tranquilizers or antipsychotic medication
  • known disease of the CNS
  • score less than 24/30 points in MMSE

Trial design

279 participants in 2 patient groups

Patients with POCD - cases
Description:
Out of the 976 patients included in the ISPOCD2 study (Abildstrom H, Christiansen M et al. Apolipoprotein E genotype and cognitive dysfunction after noncardiac surgery. Anesthesiology 2004;101:855-61) the 93 patients with POCD whose blood samples are stored will be included together with 2x93 controls (without POCD), who will be matched by type of surgery, age, education, ASA-score and sex.
Treatment:
Genetic: Genotyping
Patients without POCD - controls
Description:
Out of the 976 patients included in the ISPOCD2 study (Abildstrom H, Christiansen M et al. Apolipoprotein E genotype and cognitive dysfunction after noncardiac surgery. Anesthesiology 2004;101:855-61) the 93 patients with POCD whose blood samples are stored will be included together with 2x93 controls (without POCD), who will be matched by type of surgery, age, education, ASA-score and sex.
Treatment:
Genetic: Genotyping

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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