Study of the Correlation Between Specific Genes and Cognitive Dysfunction After Surgery

Herlev Hospital

Status: Completed

Conditions: Genotype; Cognitive Impairment

Treatments: Genetic: Genotyping

Study type: Observational

Funder types: Other

Identifiers

NCT01088100

MVH-01

Details and patient eligibility

About

The purpose of this study is to determine whether a certain clock-gene (HPER3) with the 5/5 genotype carries a higher risk of post-operative cognitive dysfunction.

Enrollment: 279 patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing non-cardiac and non-neurological surgery in either regional or general anesthesia

Exclusion criteria

• daily use of major tranquilizers or antipsychotic medication
• known disease of the CNS
• score less than 24/30 points in MMSE

Trial design

279 participants in 2 patient groups

Patients with POCD - cases

Description:

Out of the 976 patients included in the ISPOCD2 study (Abildstrom H, Christiansen M et al. Apolipoprotein E genotype and cognitive dysfunction after noncardiac surgery. Anesthesiology 2004;101:855-61) the 93 patients with POCD whose blood samples are stored will be included together with 2x93 controls (without POCD), who will be matched by type of surgery, age, education, ASA-score and sex.

Treatment:

Genetic: Genotyping

Patients without POCD - controls

Description:

Out of the 976 patients included in the ISPOCD2 study (Abildstrom H, Christiansen M et al. Apolipoprotein E genotype and cognitive dysfunction after noncardiac surgery. Anesthesiology 2004;101:855-61) the 93 patients with POCD whose blood samples are stored will be included together with 2x93 controls (without POCD), who will be matched by type of surgery, age, education, ASA-score and sex.

Treatment:

Genetic: Genotyping