Study of the Cutaneous Reinnervation After Burn (NERVAL)

Regional University Hospital Center (CHRU)

Status: Terminated

Conditions: Post-burn Innervation

Treatments: Procedure: Skin biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT02356354

RB 14.190 NERVAL

Details and patient eligibility

About

The aim of this study is to understand why the regeneration of the cutaneous sensory nerve fibers is poor in post-burn scar.

The presence or the lack of several molecular factors known to regulate neuronal cell development will be evaluate and compared within biopsies from healthy skin and post-burn scar.

Enrollment: 6 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Major patients
• At least one year back deep burn (2nd and 3rd degrees), and allowing the comparison between the post-burn scar dermatome and the healthy opposite dermatome
• Patients always followed in the service of Plastic surgery of the hospital of Brest
• Informed consent and paper of the patient after information of the objective of the study and the protocol
• Analog Visual scales for pain and/or pruritus (EVA): greater than or equal to 3
• Simple Verbal scales for the pain and/or the pruritus ( EVS): pain / pruritus moderated to intense
• Membership to the Social Security

Exclusion criteria

• Allergy to xylocaine
• Non-Caucasian patients
• Treatments having an effect on the pain and/or the pruritus
• Sun or UV exposure several days preceding or following the biopsies

Trial design

6 participants in 1 patient group

Skin biopsy

Other group

Description:

On the same patient, a biopsy of post-burn scar is removed. A second one is removed from healthy skin.

Treatment:

Procedure: Skin biopsy