Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation in Analgetic Dosages

Ruhr University of Bochum

Status: Completed

Conditions: Platelet Aggregation

Treatments: Drug: dipyrone; Other: Blood samples; Drug: Parecoxib/Valdecoxib; Drug: Acetaminophen; Drug: Ibuprofen

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00763997

NRA3480005

Details and patient eligibility

About

Dipyrone is suggested to inhibit the platelet aggregation comparable to th effect of traditional analgetic substances like Ibuprofen. To verify this hypothesis the investigators conducted the study in comparing patients undergoing traumatologic, visceral or plastic surgical procedures. The investigators randomized them to four groups receiving common analgetic doses of either dipyrone, acetaminophen (paracetamol) or valdecoxib/parecoxib. The investigators took blood samples before initiation of the study drug, 1h, 4hs and 24hs after first intake. The investigators compared the aggregation via aggregometry of platelet rich plasma.

Enrollment: 80 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Planned traumatologic, orthopedic, visceral or plastic surgical procedures

Exclusion criteria

• Prior intake of drugs with effect on the platelet aggregation
• Patients with diseases of the gastrointestinal systems
• Patients with cardiac or circulatory diseases
• Patients receiving corticoids
• Patients with cold or asthma
• ASA-classification > 3

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 4 patient groups, including a placebo group

1

Experimental group

Description:

Dipyrone

Treatment:

Other: Blood samples

Drug: dipyrone

2

Active Comparator group

Description:

Ibuprofen

Treatment:

Other: Blood samples

Drug: Ibuprofen

3

Active Comparator group

Description:

Acetaminophen

Treatment:

Drug: Acetaminophen

Drug: Acetaminophen

Other: Blood samples

4

Placebo Comparator group

Description:

Parecoxib/Valdecoxib

Treatment:

Drug: Parecoxib/Valdecoxib

Other: Blood samples