Study of the Effect of Fluticasone Furoate Nasal Spray on Spring Allergy Eye Symptoms

Rush

Status and phase

Completed

Phase 4

Conditions

Allergic Conjunctivitis to Tree Pollen or Grass Pollen

Treatments

Drug: Fluticasone furoate nasal spray

Drug: Placebo nasal spray

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00891436

RUMCgsk 113002

Details and patient eligibility

About

Rationale and objectives:

Fluticasone furoate nasal spray (Veramyst) has been shown to improve ocular symptoms when used for the treatment of seasonal allergic rhinitis during the ragweed pollen season. Although this is the only published report of an intranasal corticosteroid shown to effectively treat ocular symptoms, the mechanism has not been delineated. Furthermore, the tears of patients with allergic conjunctivitis are known to have increased concentrations of cytokines and allergic mediators.

The objective of this study is to determine if the positive effects of Veramyst nasal spray on ocular symptoms is via the inhibition of allergic mediators in the eyes. The investigators will conduct a double blind placebo controlled trial to determine if Veramyst nasal spray decreases the amount of allergic mediators in the tears of subjects randomized to Veramyst nasal spray versus placebo. The investigators will also compare the subjects' symptoms to the amount of allergic mediators detected in their tears.

Enrollment

20 patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

a documented history of allergic rhinitis and conjunctivitis due to tree pollen and / or grass pollen for two allergy seasons
positive skin prick test to tree and / or grass

Exclusion criteria

glaucoma
cataracts
acute or chronic sinusitis
asthma
chronic obstructive pulmonary disease
physical nasal obstruction
pregnant or breastfeeding
have had a viral or bacterial infections within 2 weeks of the study commencement
receiving allergen immunotherapy
have used inhaled corticosteroids within 14 days prior to the study
have used systemic corticosteroids within 30 days of the study
travel outside of the geographic area during the 2 week study period
use of contact lenses during the study period
use of artificial tears during the study period
use of eyewash irrigation during the study period
use of lubricants during the study period