Study of the Effect of Magnetic Stimulation Repetitive Transcranial on Impulsivity in Cocaine Dependence (TMSCOCAINE)

University of Sao Paulo General Hospital

Status and phase: Unknown; Phase 2

Conditions: Cocaine Dependence

Treatments: Procedure: Placebo TMS; Procedure: Transcranial Magnetic Stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT01397266

1339/09

Details and patient eligibility

About

In a randomized, double-blind controlled trial the investigators will evaluate the efficacy of rTMS in reducing impulsivity for cocaine addicts through - Quantitative and qualitative analysis - such behavior and possible behavioral consequences related.

Full description

reduction of the rating impulsivity

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Diagnosis of the cocaine dependence syndrome, alone or in combination with abuse of alcohol and nicotine dependence (DSM IV, 1994; SCID-P, 1994).
2. 20 days or less withdrawal
3. 18-35 years old.
4. If female, to be using contraception (barrier, oral contraceptive, IUD, surgical sterilization).
5. Fixed residential address in Sao Paulo

Exclusion criteria

1. Other Mental Disorders (DSM IV, 1994; SCID-P, 1994).
2. organic brain disease, neurosurgery to implant metal clip or epilepsy.
3. severe uncontrolled clinical comorbidity.
4. use current or within last six months of psychotropic drugs in general, except for Clonazepam dose of up to four mg / day.
5. Changes clinically significant laboratory findings. 13
6. Condition or situation to which in the opinion of the investigator put the patient at risk significant, which may confound the results, or interfere substantially in individual's participation in the study.
7. Mandate that mandating the judicial treatment for cocaine dependence

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 2 patient groups, including a placebo group

Active TMS

Active Comparator group

Description:

active rTMS delivered to the left dorsolateral prefrontal cortex

Treatment:

Procedure: Transcranial Magnetic Stimulation

Placebo TMS

Placebo Comparator group

Description:

PLACEBO rTMS delivered to the left dorsolateral prefrontal cortex

Treatment:

Procedure: Placebo TMS