Study of the Effect of Oral Zinc Supplementation on Superoxide Radical Scavengers

Babylon University

Status and phase: Completed; Phase 2

Conditions: Asthenozoospermia

Treatments: Dietary Supplement: zinc sulfate

Study type: Interventional

Funder types: Other; NETWORK

Identifiers

NCT02217189

Babil-3

Details and patient eligibility

About

Although several studies have considered the relationship between infertility and semen super oxide radical scavengers levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on superoxide radical scavengers activity which are important in fertility of the individual has been reported.

Full description

The present study was conducted to study the effect of zinc supplementation on the quantitative and qualitative characteristics of semen along with superoxide radical scavengers activity in the seminal plasma of asthenospermic patients.

Enrollment: 120 patients

Sex: Male

Ages: 26 to 36 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• the presence of asthenozoospermia in the semen sample.

Exclusion criteria

• the absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

Zinc sulfate

Experimental group

Description:

60 subfertile (age 32.5±3.23 year) men with asthenozoospermia was treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Treatment:

Dietary Supplement: zinc sulfate

Healthy control

No Intervention group

Description:

60 fertile (age 31.6±3.3 year) men, no treatment.