Study of the Effect of Vagus Nerve Stimulation on Human Brown Adipose Tissue Activity

Maastricht University

Status: Unknown

Conditions: Obesity

Treatments: Other: Enabling and disabling VNS

Study type: Observational

Funder types: Other

Identifiers

NCT01491282

MEC 10-3-071

Details and patient eligibility

About

To evaluate the effect of vagus nerve stimulation for refractory epilepsy on the activity of human brown adipose tissue.

Enrollment: 5 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects treated with VNS for epilepsy, aged 18-65 years, with a Body Mass Index (BMI) ≤ 28 kg/m2.

Exclusion criteria

• Body Mass Index > 28 kg/m2

• Daily epileptic insults.

• Subjects that need 'Rapid Cycling' VNS to control their frequency of epileptic insults.

• Psychological unstable subjects (as judged by the treating neurologist).

• subjects with mental retardation (as judged by the treating neurologist).

• subjects with severe behaviour disorders (as judged by the treating neurologist).

• Pregnant subjects.

• Subjects that previously underwent high dose radiation for diagnostic or therapeutic purposes (radiotherapy, high frequency CT-scans).

• The use of the following medication is an exclusion criterium;

  • ß-blockers,
  • Ketogenic diet

Trial design

5 participants in 1 patient group

No treatment

Treatment:

Other: Enabling and disabling VNS