Study of the Effects of Muscular Activity on Iron Metabolism

Rennes University Hospital

Status: Unknown

Conditions: Iron Deficiency; Iron Overload

Treatments: Behavioral: 45 minute exercise on ergocycle

Study type: Interventional

Funder types: Other

Identifiers

NCT00378469

LOC/05-07

CIC0203/061

DGS 2006/0415

Details and patient eligibility

About

The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will have to pedal on an ergocycle for 45 minutes, and urine and blood samples will be collected regularly to measure hemojuvelin, hepcidin, iron and transferrin levels.

Full description

Hemojuvelin has been described as interfering with hepcidin, a key regulator of iron homeostasis. Hemojuvelin is mainly produced by muscle, and the relationship between exercise and iron metabolism can be questioned about.

The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will be investigated at two periods according to a cross-over design after:

1. 45 minutes of exercise on the ergocycle; and
2. no physical exercise.

Urine and blood samples will be collected at both periods regularly to measure hemojuvelin, hepcidin, iron and transferrin levels.

Enrollment: 14 estimated patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male individuals aged between 18 and 40 years old
• Body mass index (BMI) between 18 and 25
• Normal at clinical examination
• Normal biological variables
• Written informed consent

Exclusion criteria

• Mutation C282Y of the HFE gene
• Iron metabolism abnormality
• Inflammatory syndrome
• Chronic pathology or ongoing treatment
• Tobacco smoking, alcohol consuming more than 30g/day
• History of transfusion or blood-giving within 3 months
• Positive serology for hepatitis B virus (HBV), hepatitis C virus (HCV) or HIV.