Study of the Efficacy of Local Analgesia as an Adjunct to General Anesthesia in Thyroidectomy and Parathyroidectomy

The University of Chicago

Status: Completed

Conditions: Thyroid Nodule; Hyperparathyroidism; Goiter, Nodular; Thyroid Neoplasms; Graves' Disease

Treatments: Procedure: Superficial Cervical Plexus Block; Procedure: Local Wound Infiltration; Drug: Marcaine; Drug: 0.9% saline

Study type: Interventional

Funder types: Other

Identifiers

NCT02205801

IRB14-0374

Details and patient eligibility

About

We aim to study the effect of local anesthetic when used in conjunction with general anesthesia during thyroidectomy or parathyroidectomy. We hypothesize there is equivalent pain control between bilateral superficial cervical plexus block and local wound infiltration when used in conjunction with a general anesthetic.

Enrollment: 36 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient ≥ 18 years old
• Surgical indication for parathyroidectomy or thyroidectomy

Exclusion criteria

• Patients < 18 years old
• Patient with history of chronic opioid use
• Patient with chronic pain syndromes
• Patient with allergy to marcaine

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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36 participants in 4 patient groups, including a placebo group

superficial cervical block, active

Active Comparator group

Description:

After induction of general anesthesia the surgeon will perform a bilateral superficial cervical plexus block using 0.25% Marcaine.

Treatment:

Procedure: Superficial Cervical Plexus Block

Drug: Marcaine

local wound infiltration, placebo

Placebo Comparator group

Description:

After induction of general anesthesia the surgeon will perform local wound infiltration using 0.9% Saline.

Treatment:

Procedure: Local Wound Infiltration

Drug: 0.9% saline

local wound infiltration, active

Active Comparator group

Description:

After induction of general anesthesia the surgeon will perform a local wound infiltration using 0.25% Marcaine.

Treatment:

Procedure: Local Wound Infiltration

Drug: Marcaine

superficial cervical block, placebo

Placebo Comparator group

Description:

After induction of general anesthesia the surgeon will perform a bilateral superficial cervical plexus block using 0.9% saline.

Treatment:

Procedure: Superficial Cervical Plexus Block

Drug: 0.9% saline