STUDY OF THE EXPRESSION OF CIRCULATING AND INTRA-TUMORAL CHEMOKINES IN PATIENTS WITH PROSTATE CANCER (CHEMOPROST)

Institut Bergonié

Status

Unknown

Conditions

Prostate Cancer

Treatments

Other: Urine samples

Other: Blood samples

Study type

Observational

Funder types

Other

Identifiers

NCT02869282

IB2011-CHEMOPROST

Details and patient eligibility

About

Multicentric, observational, prospective, non-interventional study with occasional biological sample collection (serum bank, urine bank and tumor bank)

Full description

This project is an exploratory study, based on the hypothesis of involvement of chemokines in hormonal escape of prostate cancers.

The two main objectives are:

To describe the variations in expression of chemokines in serum and urine level in patients with prostate cancer
And to study the disease stage and intra-prostatic concentrations of chemokines based on serum and urine concentrations of chemokines before treatment initiation.

These estimates can be used in future trials set up for the management of prostate cancer

Enrollment

145 estimated patients

Sex

Male

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with a localized or metastatic prostate adenocarcinoma for which a new treatment will be implemented (hormone therapy for single biological relapse or relapses and metastatic hormone-sensitive) or chemotherapy (for biological relapses and / or metastatic hormone-resistant)
Patients with a detectable PSA (Prostate-Specific Antigen)
Patients who signed an informed consent
Patients over 18 years
Patients belonging to the social security scheme

Exclusion criteria