Circulating And Intra-Tumoral Chemokines In Patients With Prostate Cancer (CHEMOPROST)

Institut Bergonié

Status: Withdrawn

Conditions: Prostate Cancer

Treatments: Other: Urine samples; Other: Blood samples

Study type: Observational

Funder types: Other

Identifiers

NCT02869282

IB2011-CHEMOPROST

Details and patient eligibility

About

Multicentric, observational, prospective, non-interventional study with occasional biological sample collection (serum bank, urine bank and tumor bank)

Full description

This project is an exploratory study, based on the hypothesis of involvement of chemokines in hormonal escape of prostate cancers.

The two main objectives are:

• To describe the variations in expression of chemokines in serum and urine level in patients with prostate cancer
• And to study the disease stage and intra-prostatic concentrations of chemokines based on serum and urine concentrations of chemokines before treatment initiation.

These estimates can be used in future trials set up for the management of prostate cancer

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with a localized or metastatic prostate adenocarcinoma for which a new treatment will be implemented (hormone therapy for single biological relapse or relapses and metastatic hormone-sensitive) or chemotherapy (for biological relapses and / or metastatic hormone-resistant)
• Patients with a detectable PSA (Prostate-Specific Antigen)
• Patients who signed an informed consent
• Patients over 18 years
• Patients belonging to the social security scheme

Exclusion criteria

• Active Hepatitis B or C virus
• HIV positive
• Patients who have received prior chemotherapy
• Patients with a second neoplasia treated in the last 5 years

Trial design

0 participants in 1 patient group

Prospective cohort

Description:

Levels of CXCL1, CCL5, CXCL8 and CXCL12 chemokines and of IL-6 cytokine by ELISA or Luminex technology.

Treatment:

Other: Blood samples

Other: Urine samples