Study of the Glutaminase Inhibitor CB-839 in Solid Tumors

Calithera Biosciences

Status and phase: Completed; Phase 1

Conditions: Fumarate Hydratase (FH)-Deficient Tumors; Succinate Dehydrogenase (SDH)-Deficient Gastrointestinal Stromal Tumors (GIST); Mesothelioma; Non Small Cell Lung Cancer; Tumors Harboring Isocitrate Dehydrogenase-1 (IDH1) and IDH2 Mutations; Renal Cell Carcinoma; Solid Tumors; Tumors Harboring Amplifications in the cMyc Gene; Triple-Negative Breast Cancer; Succinate Dehydrogenase (SDH)-Deficient Non-gastrointestinal Stromal Tumors

Treatments: Drug: CB-Erl; Drug: CB-Cabo; Drug: Pac-CB; Drug: CB-839; Drug: CBE; Drug: CBD

Study type: Interventional

Funder types: Industry

Identifiers

NCT02071862

CX-839-001

Details and patient eligibility

About

Many tumor cells, in contrast to normal cells, have been shown to require the amino acid glutamine to produce energy for growth and survival. To exploit the dependence of tumors on glutamine, CB-839, a potent and selective inhibitor of the first enzyme in glutamine utilization, glutaminase, will be tested in this Phase 1 study in patients with solid tumors.

This study is an open-label Phase 1 evaluation of CB-839 in patients with advanced solid tumors. The study will be conducted in 2 parts. Part 1 is a dose escalation study enrolling patients with locally-advanced, metastatic and/or refractory solid tumors to receive CB-839 capsules orally twice or three times daily.

In Part 2, patients with each of the following diseases will be enrolled: A) Triple-Negative Breast Cancer, B) Non-Small Cell Lung Cancer (adenocarcinoma), C) Renal Cell Cancer, D) Mesothelioma, E) Fumarate hydratase (FH)-deficient tumors, F) Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GIST), G) SDH-deficient non-GIST tumors, H) tumors harboring mutations in isocitrate dehydrogenase-1 (IDH1) or IDH2, and I) cMyc mutation tumors.

As an extension of Parts 1 & 2, patients will be treated with CB-839 in combination with standard chemotherapy. Combination groups include: Pac-CB, CBE, CB-Erl, CBD, and CB-Cabo. Pac-CB: patients with locally-advanced or metastatic TNBC will be treated with paclitaxel and CB-839. CBE: patients with advanced clear cell RCC or papillary RCC will be treated with everolimus in combination with CB-839. CB-Erl: patients with advanced NSCLC lacking the T790M EGFR mutation will be treated with erlotinib and CB-839. CBD: patients with NSCLC harboring KRAS mutation will be treated with docetaxel and CB-839. CB-Cabo: patients with histologically confirmed diagnosis of locally-advanced, inoperable or metastatic RCC treated with cabozantinib in combination with CB-839.

All patients will be assessed for safety, pharmacokinetics (plasma concentration of drug), pharmacodynamics (inhibition of glutaminase), biomarkers (biochemical markers that may predict responsiveness in later studies), and tumor response.

Enrollment: 210 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria

• Advanced malignancy that is relapsed and/or refractory to all available therapies that will confer clinical benefit. Newly diagnosed patients who refuse standard treatment regimens are also eligible
• Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1
• Life Expectancy of at least 3 months
• Adequate hepatic, renal, cardiac, and hematologic function
• Measurable disease by RECIST criteria
• Ability to provide written informed consent in accordance with federal, local, and institutional guidelines

Exclusion Criteria

• Any other current or previous malignancy
• Chemotherapy, radiation therapy, hormonal therapy, immunotherapy or biological therapy, or investigational agent within 21 days
• Unable to receive medications oral medications
• Major surgery within 28 days before Cycle 1 Day 1
• Active infection requiring within 2 weeks prior to first dose of study drug
• Patients who have HIV, Hepatitis A, B or C or CMV reactivation
• Significant neurotoxicity/neuropathy (Grade 3 or higher) within 14 days of first dose of study drug
• Conditions that could interfere with treatment or protocol-related procedures

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

---

210 participants in 6 patient groups

CB-839

Experimental group

Description:

CB-839 administered as oral capsules two (BID) or three times daily (TID) in 21-day cycles until disease progression or unacceptable toxicity

Treatment:

Drug: CB-839

Pac-CB

Experimental group

Description:

CB-839 administered as oral capsules twice daily (BID) in combination with standard dose paclitaxel in 28-day cycles until disease progression or unacceptable toxicity

Treatment:

Drug: CB-839

Drug: Pac-CB

CBE

Experimental group

Description:

CB-839 administered as oral capsules twice daily (BID) in combination with standard dose everolimus in 28-day cycles until disease progression or unacceptable toxicity

Treatment:

Drug: CBE

Drug: CB-839

CB-Erl

Experimental group

Description:

CB-839 administered as oral capsules twice daily (BID) in combination with standard dose erlotnib in 28-day cycles until disease progression or unacceptable toxicity

Treatment:

Drug: CB-839

Drug: CB-Erl

CBD

Experimental group

Description:

CB-839 administered as oral capsules twice daily (BID) in combination with standard dose docetaxel in 21-day cycles until disease progression or unacceptable toxicity

Treatment:

Drug: CBD

Drug: CB-839

CB-Cabo

Experimental group

Description:

CB-839 administered as oral capsules twice daily (BID) in combination with standard dose cabozantinib in 28-day cycles until disease progression or unacceptable toxicity

Treatment:

Drug: CB-Cabo