Study of the Glycocalyx in Abdominal Aortic Aneurysm (Endo_eAAA)

Rigshospitalet

Status: Unknown

Conditions: Surgery; Ischemic Reperfusion Injury; Abdominal Aortic Aneurism

Treatments: Other: Plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT01834092

H-4-2012-085

Details and patient eligibility

About

The investigators want to measure the degradation of the endothelial glycocalyx before and after clamping the aorta, in patients operated for a abdominal aortic aneurism.

Full description

50 patients is scheduled for enrollment. Blood samples will be up taken before surgery, 10 min after reperfusion, at the end of surgery and the following morning. In addition the investigators are placing a renal venous catheter where blood samples will be up taken as mentioned above for the analysis of endothelial markers together with markers for kidney damage.

The first 10 patient will act as part of a pilot study, where only measurement of the endothelial and renal failure markers will be performed.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• above 18 years

Exclusion criteria

• prior engagement in scientific study within the last 30 days.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

---

50 participants in 2 patient groups

Fresh frozen plasma

Active Comparator group

Description:

2 portions of FFP will be transfused prior to reperfusion

Treatment:

Other: Plasma

Fresh non-frozen plasma

Experimental group

Description:

2 portions of non-frozen plasma will be transfused prior to reperfusion

Treatment:

Other: Plasma