Study of the Hemispheric Specialization for Language in Subjects With Neuropsychiatric Disorders Compared to Control Subjects (BIP)

Caen University Hospital

Status: Completed

Conditions: Neuropsychiatric Disorders

Treatments: Other: language task and a reference task (rest and Tamil); Device: IMRf

Study type: Interventional

Funder types: Other

Identifiers

NCT02523742

05-097

Details and patient eligibility

About

Recently, we have shown functional resonance imaging (fMRI) that variations in signal induced by a language task were significantly lower in a semantic region of the left hemisphere (comprised of that part pars triangularis of the inferior frontal gyrus and the temporal gyri medium and angular) in schizophrenic patients compared with controls matched for age, sex, level of education and handedness.

Investigators wish to test the hypothesis that functional modification of the hemispherical specialization is specific language and also specific for schizophrenia.

Enrollment: 152 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients under 65 years
• Schizophrenics, bipolar or schizoaffective (DSM IV)
• Patients who signed informed consent

Exclusion criteria

• Women with childbearing potential without effective contraception or positive pregnancy test.
• Contra-indications to fMRI

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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152 participants in 2 patient groups

Neuropsychiatric Disorders

Other group

Description:

Neuropsychiatric Disorders patients

Treatment:

Other: language task and a reference task (rest and Tamil)

Device: IMRf

Healthy volunteers

Other group

Description:

control subjects matched to patients by age, sex, socio-cultural level and laterality

Treatment:

Other: language task and a reference task (rest and Tamil)

Device: IMRf