Study of the Immune Response After Vaccination in Multiple Myeloma Patients

Wake Forest University (WFU)

Status: Completed

Conditions: Multiple Myeloma; Myeloma, Multiple; Myeloma-Multiple

Study type: Observational

Funder types: Other

Identifiers

NCT02294487

MMvax-pilot

Details and patient eligibility

About

This study will collect blood samples from healthy volunteers and volunteers with multiple myeloma who are going to get the seasonal flu, pneumonia, haemophilus influenzae B (HIB), and/or meningococcus vaccines.

The main goal of the study is to start to identify differences in the immune response between multiple myeloma patients and people who don't have multiple myeloma. We hope this will provide important information about the best way and time to vaccinate multiple myeloma patients to flu, pneumonia, haemophilus influenzae B (HIB), and/or meningococcus .

Full description

This study will consist of a prospective blood sample collection to gather baseline data to confirm antibody protection from vaccines in the Aurora Health Care multiple myeloma (MM) patients.

The overall goal of this study is to obtain a normative dataset for MM patients and non-MM control populations as well as determining baseline IgG levels to seasonal influenza A, influenza B, pneumococcal polysaccharide, and tetanus toxoid and confirmation of antibody protection from vaccines with assays based upon WHO standards of detection.

This is part of a series of studies designed to provide important information about the best way and time to vaccinate MM patients to flu, pneumonia, haemophilus influenzae B (HIB), and/or meningococcus and to gather additional information about MM and immune function.

Enrollment: 19 patients

Sex: All

Ages: 50+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 50 years old or over
• planning on getting the seasonal flu and/or pneumonia vaccine as part of normal care
• have multiple myeloma, or don't have multiple myeloma and want to serve as a health control

Exclusion criteria

• do not meet inclusion criteria

Trial design

19 participants in 1 patient group

Subjects

Description:

Individuals over 50 who are going to get the seasonal flu vaccine, pneumococcal, HIB, and/or meningococcal vaccination and either have multiple myeloma or do not have multiple myeloma.