Study of the Innate Immune Response to the Acute Phase of Human Leptospirosis - IMMUNOLEPTO

Centre Hospitalier Universitaire de la Réunion

Status

Completed

Conditions

Leptospirosis

Treatments

Other: two additional blood samples specific to research

Study type

Interventional

Funder types

Other

Identifiers

NCT05413720

2017/CHU/14

Details and patient eligibility

About

The research hypothesis is based on a suspected strong involvement of the immune system in the genesis of serious manifestations of the disease (hepatitis, renal failure, thrombocytopenia, intra-alveolar hemorrhage). The question asked is that of the state of the immune system (quantitative and qualitative: activation markers, production of cytokines) evaluated by the study of circulating innate immune cells (monocytes, neutrophils, dendritic cells, lymphocytes, platelets).

Enrollment

100 patients

Sex

All

Ages

4+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥ 4 years;
Weight ≥ 11 kg;
with ongoing symptoms compatible with a clinical diagnosis of leptospirosis.
AND having a diagnosis of leptospirosis confirmed according to standard care procedures: preferably by Polymerase Chain Reaction (PCR) (blood or urine) or, failing that, serology indicating a recent infection (positive Immunoglobulin M (IgM) or Microscopic Agglutination Test (MAT) technique with titer >1/400 for a pathogenic serogroup)
AND affiliated to a Social Security scheme

Exclusion criteria

Refusal of participation by the patient or his entourage if the patient is physically unable to give his opinion (coma, resuscitation, etc.).
Not affiliated with social security
Immunosuppression that may interfere with the interpretation of the results: chemotherapy in progress, immunosuppressants in progress for organ transplantation or autoimmune disease
Patient under legal protection (Guardianship, Curators)