Study of the Interactions Between Dientamoba Fragilis and the Gut Microbiota

University Hospital, Strasbourg, France

Status: Terminated

Conditions: Diarrhea

Treatments: Other: Stool sampling and sequencing of gut microbiota.

Study type: Observational

Funder types: Other

Identifiers

NCT02534272

6110

Details and patient eligibility

About

D.fragilis is an intestinal protozoon that feeds by phagocytosis of intestinal bacteria. The study aim to determine if the carriage of the intestinal parasite D.fragilis is associated to changes of gut microbiota in subjects presenting with or without intestinal symptoms.

Enrollment: 27 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for symptomatic group:

• male/female aged at least of 18 years
• subject with abdominal pain, diarrhea, bloating
• no other known intestinal disease

Inclusion Criteria for asymptomatic group:

• male/female aged at least of 18 years
• no known intestinal disease

Exclusion Criteria of symptomatic and asymptomatic groups:

• chronic intestinal diseases such as IBD, IBS ...
• intake of antibiotic or probiotic within the 2 last months
• subject in exclusion period
• subject unable to understand information for a free consent to the study
• subject in safeguarding justice or guardianship

Trial design

27 participants in 2 patient groups

Symptomatic subjects

Description:

Subjects with intestinal symptoms

Treatment:

Other: Stool sampling and sequencing of gut microbiota.

Asymptomatic subjects

Description:

Subjects without intestinal symptoms

Treatment:

Other: Stool sampling and sequencing of gut microbiota.