Study of the Intermediate Metabolism in Children With Acute Lymphoblastic Leukemia (ALL)

Aristotle University Of Thessaloniki

Status

Unknown

Conditions

Acute Lymphoblastic Leukemia, Pediatric

Metabolism Disorder

Treatments

Other: Metabolome study

Study type

Observational

Funder types

Other

Identifiers

NCT03035344

CHILDHOOD ALL METABOLOMICS

Details and patient eligibility

About

Study of the intermediate metabolism in children diagnosed with ALL compared to healthy matched controls.

Full description

The primary cause of this study is to investigate the changes that ALL may cause to the metabolome of pediatric patients, in order to better understand its mechanism of action and target metabolic pathways for potential therapies.

Enrollment

25 estimated patients

Sex

All

Ages

1 month to 16 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Sex: all
Minimum age: 1 year
Maximum age: 16 years
The study accepts healthy volunteers as matched controls for the patinets.
Inclusion criteria: 1)Children diagnosed with ALL 2) Diagnosis confirmed with bone marrow biopsy 3) Sampling before the initiation of therapy 4) Informed consent signed
Exclusion Criteria: 1) Children with a known chronic illness before ALL diagnosis 2) ALL remission 3) Not signed informed consent
Population description: Patients are recruited from the Pediatric Hematology/Oncology Department of Aristotle University of Thessaloniki (AHEPA hospital) and from the Pediatric Hematology/ Oncology Department of Ippokration Hospital, that host all children diagnosed with ALL in nothern Greece. Matched controls are recruited from outpatient clinic of the 2nd and 4th Pediatric Department of Aristotle University of Thessaloniki.
Sampling method: Non-probability sample