Study of the Involvement of Fatty Acids in Retinopathy of Prematurity: Relationship Between Retinopathy of Prematurity and the Rate of Expression of Transplacental Fatty Acid Receptors. (OMEGAROP 2)

University Hospital Center (CHU) Dijon Bourgogne

Status

Enrolling

Conditions

Retinopathy

Prematurity

Treatments

Biological: Umbilical cord blood sampling

Other: Data collection

Biological: Placenta sampling

Biological: Maternal blood sampling

Study type

Observational

Funder types

Other

Identifiers

NCT04819893

CREUZOT-GARCHER 2020-1

Details and patient eligibility

About

The development of the retinal vascular network is completed during the third trimester of pregnancy and and the first 15 days of life of the newborn. This late maturation can be problematic in cases of preterm births and result in immature retinal vascularization, known as retinopathy of prematurity (ROP). Among the various factors influencing retinal vascular development, the tissue content of omega-3 polyunsaturated fatty acids (PUFAs) appears to be a crucial element. In a previous project, OMEGA-ROP, we showed a difference in the blood bioavailability of omega-3 PUFAs in infants born at less than 28 weeks of amenorrhea who develop ROP compared to healthy newborns with no retinopathy. This study also showed that mothers experienced variations in the blood levels of omega-3 PUFAs that were contrary to the types of variations observed in their children. This suggests a sequestration of omega-3 PUFAs in the mothers of children who will develop ROP. This new project aims to better understand the underlying molecular mechanisms by studying the expression levels of placental fatty acid receptors in relation to the development of ROP in newborns.

Enrollment

135 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Mothers giving birth to premature babies less than 29 weeks of amenorrhea (WA), after obtaining their non-opposition.
Mothers giving birth at term between 39 and 41WA+6 days, after obtaining their non-opposition.
≥18 years
Mothers not under legal protection

Exclusion criteria

Mothers giving birth between 29WA and 38WA+6 days
Mothers in critical condition.
Person not affiliated to national health insurance
For full-term mothers: patient presenting or having presented a health condition that affected a previous pregnancy (vascular such as pregnant hypertension, preeclampsia; gestational diabetes; intrauterine growth retardation, maternal infection during pregnancy such as toxoplasmosis, cytomegalovirus, rubella, measles, chickenpox).