Study of the Laboratory-based Evaluation of the Degrees of Activity of Osteoarthritis

The Republican Research and Practical Center for Epidemiology and Microbiology

Status: Completed

Conditions: Osteoarthritis

Study type: Observational

Funder types: Other

Identifiers

NCT03164070

RRPCEM_OA

Details and patient eligibility

About

This study evaluates laboratory-based method to estimate the degrees of activity of medium and large joint osteoarthritis.

Full description

Osteoarthritis (OA) is a chronic progressive disease, characterized by degradation of joint cartilage, synovial inflammation and joint dysfunction. This study evaluates laboratory-based method to estimate the degrees of activity of medium and large joint OA. Samples of synovial fluid (SF) from the patients with the OA (ICD-10 codes: M15, M16 and M17) will be assessed for T-cell subsets, msast cells, fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) by flow cytometry. Subpopulations of blood T-cells involved in the inflammation will also be assayed. Standard clinical investigation will be performed and the results will be used to estimate the laboratory criteria or degrees of activity of medium and large joint OA.

Enrollment: 121 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• medium and large joint active osteoarthritis

Exclusion criteria

• refuse of patient to participate in the trial;
• acute infectious diseases;
• pregnancy/lactation;
• intercurrent severe chronic diseases;
• HIV, Hepatites B/C;
• active tuberculosis;
• alcohol use disorder/drug addiction;
• malignant neoplasms/leukemia.

Trial design

121 participants in 2 patient groups

Patients with osteoarthritis

Description:

Patients with medium and large joint osteoarthritis

Control group

Description:

Control group of healthy persons