Study of the Level of a Protein Which Could Predict the Development of a Fungal Infection in Patients With Acute Leukemia (MBL INFFONG)

University Hospital Center (CHU) Dijon Bourgogne

Status: Completed

Conditions: Acute Leukemia; Invasive Fungal Infection

Treatments: Biological: blood sample

Study type: Observational

Funder types: Other

Identifiers

NCT02823132

Goyer APJ 2013

Details and patient eligibility

About

The aim of this study is to investigate levels of a protein, mannose binding lectin, in patients with acute leukemia who develop or not an invasive fungal infection.

Enrollment: 134 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria :

• persons who have provided written consent
• Patients with national health insurance cover
• Patients with malignant hemopathy who have been treated with chemotherapy able to induce profound neutropenia (PN < 500 / mm3) lasting more than 10 days.
• Patients with malignant hemopathy who have received an autologous bone marrow graft
• Patients with severe idiopathic medullar aplasia (PN < 500 / mm3) who need to be hospitalized for at least 10 consecutive days (with or without treatment with immunosuppressants)

Exclusion Criteria:

• Patients who have received an bone marrow PSC allograft (as such patients have a risk of aspergillosis, which appears in most cases after medullar recovery; they will not be included in the study).
• Patients who have received an autologous PSC graf (as the duration of neutropenia is in most cases less than 10 days).
• Patients whose neutropenia, retrospectively assessed, lasted less than 10 days.

Trial design

134 participants in 2 patient groups

patients who develop a fungal infection

Treatment:

Biological: blood sample

patients without fungal infection

Treatment:

Biological: blood sample