Study of the Neural Basis of Analogical Reasoning (ANALOG)

Institut National de la Santé Et de la Recherche Médicale, France

Status: Completed

Conditions: Frontotemporal Dementia; Healthy Subjects; Progressive Supranuclear Palsy

Treatments: Other: MRI imaging; Device: transcranial magnetic stimulation; Other: EEG recording; Behavioral: Neuropsychological examination

Study type: Interventional

Funder types: Other

Identifiers

NCT02236832

140662B-31 (Other Identifier)

2014-A00649-38 (Other Identifier)

C14-17'

Details and patient eligibility

About

Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.

Enrollment: 130 patients

Sex: All

Ages: 20 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Healthy subjects:

• subject affiliated to national health insurance
• informed consent signed
• normal neurological examination
• subject aged at least 20

Patients:

• FTD or PSP diagnostic criteria filled
• patient affiliated to national health insurance
• informed consent signed

Exclusion criteria

• Severe psychiatric symptomatology and psychotropic drug use
• unability to understand or perform the cognitive tasks.

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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130 participants in 5 patient groups

FTD (frontotemporal dementia) patients

Experimental group

Description:

fronto-temporal demential patients

Treatment:

Behavioral: Neuropsychological examination

Other: EEG recording

Other: MRI imaging

PSP patients

Experimental group

Description:

progressive supra nuclear palsy patients

Treatment:

Behavioral: Neuropsychological examination

Other: EEG recording

Other: MRI imaging

healthy controls

Active Comparator group

Description:

healthy control education matched, age matched and sex matched with PSP and FTD patients

Treatment:

Behavioral: Neuropsychological examination

Other: EEG recording

Other: MRI imaging

healthy participants

Experimental group

Description:

healthy participants that will participate to the TMS study.

Treatment:

Behavioral: Neuropsychological examination

Other: EEG recording

Device: transcranial magnetic stimulation

Other: MRI imaging

healthy young participants

Experimental group

Description:

Healthy participants will be included for an EEG study

Treatment:

Behavioral: Neuropsychological examination

Other: EEG recording