Study of the Prognostic Role of Gene Polymorphism in the Development of B-cell Leukemias and Lymphomas in Children of Kazakh Nationality

Asfendiyarov Kazakh National Medical University

Status

Completed

Conditions

B Cell Leukemia

Lymphoma

Treatments

Genetic: SNP analysis of the DNA

Study type

Observational

Funder types

Other

Identifiers

NCT05095155

1190

Details and patient eligibility

About

To search for a genetic marker of B-cell leukemias and lymphomas in children of Kazakh nationality, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with B-cell leukemias and lymphomas in children of Kazakh nationality and normal control will be performed.

Enrollment

400 patients

Sex

All

Ages

Under 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

ethnicity - Kazakhs in at least three generations
active disease or a history of B-line ALL or B-NHL, established on the basis of morphological, cytochemical, immunophenotypic or immunohistochemical research methods with confirmation of the fact of the disease in medical documentation
Signed voluntary informed consent of the legal representative to participate in the project

Exclusion criteria

Children suffering from other types of malignant neoplasms
Children with B-linear leukemia and lymphomas with concomitant specified genetic and chromosomal diseases
Children of non-Kazakh nationality
Absence of signed informed consent or informed refusal of the legal representative to participate in the study before starting therapy