Study of the Pronostic Impact of Immunohistochemical, Histological and Radiological Factors in Patients With Primary Central Nervous System Lymphoma.

Central Hospital, Nancy, France

Status: Unknown

Conditions: Rare Disease With Poor Outcome

Study type: Observational

Funder types: Other

Identifiers

NCT05347511

2022PI003

Details and patient eligibility

About

Primary Central Nervous System Lymphoma (PCNSL) have a specific mutational profile in comparison to systemic diffuse large cells lymphoma (DLBCLs) that can be related to the expression of immunohistochemical markers as cyclon, NPM1, CD30, and P53 which could be predictive factor for prognosis and/or chemotherapy response. The main objective of this study is to identify new prognostic factors and new potential therapeutic targets.

The secondary objectives are to correlate the histological, the radiological and the clinical's informations of these patients.

Enrollment: 94 estimated patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• PCNSL diagnosed between January 2011 and December 2019, without regard to the clinical outcome.
• Age > 18

Exclusion criteria

• Systemic DLBCL