Study of the Regulation of Parathyroid Hormone Secretion in Pseudohypoparathyroidism

National Center for Research Resources (NCRR)

Status: Completed

Conditions: Pseudohypoparathyroidism

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00004661

UCLA-541

199/11909

Details and patient eligibility

About

OBJECTIVES:

Determine the relationship between serum calcium concentrations and parathyroid hormone secretion in patients with pseudohypoparathyroidism.

Full description

PROTOCOL OUTLINE:

Patients are tested for parathyroid hormone response following sequential graded intravenous infusions of sodium citrate and calcium gluconate. Assays include ionized calcium and intact parathyroid hormone.

Sex: All

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics-- Pseudohypoparathyroidism, i.e.: Renal resistance to parathyroid hormone OR Albright hereditary osteodystrophy No other illness unless related to pseudohypoparathyroidism No pregnant women